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2G54

Crystal structure of Zn-bound human insulin-degrading enzyme in complex with insulin B chain

Summary for 2G54
Entry DOI10.2210/pdb2g54/pdb
Related2G47 2G48 2G49 2G56
DescriptorInsulin-degrading enzyme, insulin, ZINC ION, ... (5 entities in total)
Functional Keywordsprotein-peptide complex, hydrolase
Biological sourceHomo sapiens (human)
More
Cellular locationSecreted: P01308
Total number of polymer chains4
Total formula weight236605.22
Authors
Shen, Y.,Tang, W.-J. (deposition date: 2006-02-22, release date: 2006-10-24, Last modification date: 2024-02-14)
Primary citationShen, Y.,Joachimiak, A.,Rosner, M.R.,Tang, W.J.
Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.
Nature, 443:870-874, 2006
Cited by
PubMed: 17051221
DOI: 10.1038/nature05143
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.25 Å)
Structure validation

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