2FIL
Crystal Structure Analysis of the A-DNA Decamer GCGT-2'OMeA-faT-ACGC, with Incorporated 2'-O-Methylated-Adenosine (2'OMeA) and 2'-Fluoroarabino-Thymidine (faT)
Summary for 2FIL
Entry DOI | 10.2210/pdb2fil/pdb |
Related | 2FIH 2FII 2FIJ |
Descriptor | 5'-D(*GP*CP*GP*TP*(A2M)P*(TAF)P*AP*CP*GP*C)-3', COBALT HEXAMMINE(III) (3 entities in total) |
Functional Keywords | 2'-fluoroarabino acid, sugar modifications, a-form dna, dna |
Total number of polymer chains | 4 |
Total formula weight | 13499.90 |
Authors | |
Primary citation | Li, F.,Sarkhel, S.,Wilds, C.J.,Wawrzak, Z.,Prakash, T.P.,Manoharan, M.,Egli, M. 2'-Fluoroarabino- and arabinonucleic acid show different conformations, resulting in deviating RNA affinities and processing of their heteroduplexes with RNA by RNase H. Biochemistry, 45:4141-4152, 2006 Cited by PubMed: 16566588DOI: 10.1021/bi052322r PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.69 Å) |
Structure validation
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