2F9U

HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with a P2 norborane

Summary for 2F9U

Entry DOI	10.2210/pdb2f9u/pdb
Related	1A1R 1JXP 1N1L 2A4G 2A4Q 2A4R
Descriptor	NS3 protease/helicase', polyprotein, ZINC ION, ... (5 entities in total)
Functional Keywords	hcv, hepatitis c protease, ns3 protease, ketoamide inhibitor, viral protein
Biological source	Hepatitis C virus More
Total number of polymer chains	4
Total formula weight	47861.86
Authors	Venkatraman, S.,Njoroge, F.G.,Wu, W.,Girijavallabhan, V.,Prongay, A.J.,Butkiewicz, N.,Pichardo, J. (deposition date: 2005-12-06, release date: 2006-06-06, Last modification date: 2024-03-13)
Primary citation	Venkatraman, S.,Njoroge, F.G.,Wu, W.,Girijavallabhan, V.,Prongay, A.J.,Butkiewicz, N.,Pichardo, J. Novel Inhibitors of Hepatitis C NS3-NS4A Serine Protease Derived from 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid. Bioorg.Med.Chem.Lett., 16:1628-1632, 2006 Cited by PubMed: 16413182 DOI: 10.1016/j.bmcl.2005.12.046 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation