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6I58

Allosteric activation of human prekallikrein by apple domain disc rotation

Replaces:  2F83
Summary for 6I58
Entry DOI10.2210/pdb6i58/pdb
Related6I44 6I4W
DescriptorCoagulation factor XI, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... (6 entities in total)
Functional Keywordsprekallikrein, activation, high molecular weight kininogen, factor xi, blood clotting
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight69266.81
Authors
Li, C.,Pathak, M.,McCrae, K.,Dreveny, I.,Emsley, J. (deposition date: 2018-11-13, release date: 2019-03-06, Last modification date: 2024-01-24)
Primary citationLi, C.,Voos, K.M.,Pathak, M.,Hall, G.,McCrae, K.R.,Dreveny, I.,Li, R.,Emsley, J.
Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI.
J.Thromb.Haemost., 17:759-770, 2019
Cited by
PubMed: 30801944
DOI: 10.1111/jth.14418
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

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