2DHF

CRYSTAL STRUCTURES OF RECOMBINANT HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND 5-DEAZOFOLATE

Summary for 2DHF

Entry DOI	10.2210/pdb2dhf/pdb
Descriptor	DIHYDROFOLATE REDUCTASE, 5-DEAZAFOLIC ACID (3 entities in total)
Functional Keywords	oxido-reductase, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion : P00374
Total number of polymer chains	2
Total formula weight	43579.87
Authors	Davies /II, J.F.,Kraut, J. (deposition date: 1989-10-25, release date: 1990-07-15, Last modification date: 2024-02-14)
Primary citation	Davies 2nd., J.F.,Delcamp, T.J.,Prendergast, N.J.,Ashford, V.A.,Freisheim, J.H.,Kraut, J. Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate. Biochemistry, 29:9467-9479, 1990 Cited by PubMed: 2248959 DOI: 10.1021/bi00492a021 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation