2CKM
Torpedo californica acetylcholinesterase complexed with alkylene- linked bis-tacrine dimer (7 carbon linker)
Summary for 2CKM
| Entry DOI | 10.2210/pdb2ckm/pdb |
| Related | 1ACJ 1ACL 1AMN 1AX9 1CFJ 1DX6 1E3Q 1E66 1EA5 1EEA 1EVE 1FSS 1GPK 1GPN 1GQR 1GQS 1H22 1H23 1HBJ 1JGA 1JGB 1JJB 1OCE 1ODC 1QID 1QIE 1QIF 1QIG 1QIH 1QII 1QIJ 1QIK 1QIM 1QTI 1SOM 1U65 1UT6 1VOT 1VXO 1VXR 1W4L 1W6R 1W75 1W76 1ZGB 1ZGC 2ACE 2ACK 2C4H 2C58 2C5F 2C5G 2CEK 2DFP 3ACE 4ACE |
| Descriptor | ACETYLCHOLINESTERASE, N,N'-DI-1,2,3,4-TETRAHYDROACRIDIN-9-YLHEPTANE-1,7-DIAMINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total) |
| Functional Keywords | serine esterase, serine hydrolase, alzheimer's disease, nerve, muscle, synapse, membrane, hydrolase, gpi-anchor, lipoprotein, glycoprotein, cholinesterase, alternative splicing, neurotransmitter degradation |
| Biological source | TORPEDO CALIFORNICA (PACIFIC ELECTRIC RAY) |
| Total number of polymer chains | 1 |
| Total formula weight | 62260.20 |
| Authors | Brumshtein, B.,Rydberg, E.H.,Greenblatt, H.M.,Wong, D.M.,Shaya, D.,Williams, L.D.,Carlier, P.R.,Pang, Y.P.,Silman, I.,Sussman, J.L. (deposition date: 2006-04-20, release date: 2006-09-04, Last modification date: 2020-07-29) |
| Primary citation | Rydberg, E.H.,Brumshtein, B.,Greenblatt, H.M.,Wong, D.M.,Shaya, D.,Williams, L.D.,Carlier, P.R.,Pang, Y.P.,Silman, I.,Sussman, J.L. Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge. J. Med. Chem., 49:5491-5500, 2006 Cited by PubMed: 16942022DOI: 10.1021/jm060164b PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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