2CFI

The hydrolase domain of human 10-FTHFD in complex with 6- formyltetrahydropterin

Summary for 2CFI

• Entry DOI: 10.2210/pdb2cfi/pdb
• Related: 2BW0 2CQ8
• Descriptor: 10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE, SULFATE ION, 6-FORMYLTETRAHYDROPTERIN, ... (4 entities in total)
• Functional Keywords: tetrahydrofolate, folate binding, nadp, one-carbon metabolism, oxidoreductase, phosphopantetheine
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cytoplasm: O75891
• Total number of polymer chains: 1
• Total formula weight: 36866.86

Authors

Kursula, P.,Stenmark, P.,Arrowsmith, C.,Edwards, A.,Ehn, M.,Graslund, S.,Hammarstrom, M.,Hallberg, M.,Kotenyova, T.,Nilsson-Ehle, P.,Nordlund, P.,Ogg, D.J.,Persson, C.,Sagemark, J.,Schuler, H.,Sundstrom, M.,Thorsell, A.,Weigelt, J. (deposition date: 2006-02-21, release date: 2006-03-14, Last modification date: 2023-12-13)

• Primary citation: Kursula, P.,Schuler, H.,Flodin, S.,Nilsson-Ehle, P.,Ogg, D.J.,Savitsky, P.,Nordlund, P.,Stenmark, P.; Structures of the Hydrolase Domain of Human 10-Formyltetrahydrofolate Dehydrogenase and its Complex with a Substrate Analogue.; Acta Crystallogr.,Sect.D, 62:1294-, 2006; PubMed: 17057331; DOI: 10.1107/S0907444906026849

Experimental method

X-RAY DIFFRACTION (1.85 Å)