2C9W

CRYSTAL STRUCTURE OF SOCS-2 IN COMPLEX WITH ELONGIN-B AND ELONGIN-C AT 1.9A RESOLUTION

Summary for 2C9W

• Entry DOI: 10.2210/pdb2c9w/pdb
• Related: 1LM8 1LQB 1VCB
• Descriptor: SUPPRESSOR OF CYTOKINE SIGNALING 2, TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2, TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1, ... (6 entities in total)
• Functional Keywords: growth regulation, sh2 domain, signal transduction inhibitor, nuclear protein, transcription, transcription regulation, ubl conjugation pathway
• Biological source: HOMO SAPIENS (HUMAN); More
• Total number of polymer chains: 3
• Total formula weight: 43859.93

Authors

Debreczeni, J.E.,Bullock, A.,Amos, A.,Savitsky, P.,Barr, A.,Burgess, N.,Sundstrom, M.,Weigelt, J.,Arrowsmith, C.,Edwards, A.,Knapp, S. (deposition date: 2005-12-14, release date: 2006-02-22, Last modification date: 2023-12-13)

• Primary citation: Bullock, A.N.,Debreczeni, J.E.,Edwards, A.M.,Sundstrom, M.,Knapp, S.; Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase.; Proc. Natl. Acad. Sci. U.S.A., 103:7637-7642, 2006; PubMed: 16675548; DOI: 10.1073/pnas.0601638103

Experimental method

X-RAY DIFFRACTION (1.9 Å)