2B1V

Human estrogen receptor alpha ligand-binding domain in complex with OBCP-1M and a glucocorticoid receptor interacting protein 1 NR box II peptide

Summary for 2B1V

• Entry DOI: 10.2210/pdb2b1v/pdb
• Related: 1ZKY 2B1V 2B1Z
• Descriptor: Estrogen receptor, Nuclear receptor coactivator 2, 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL, ... (4 entities in total)
• Functional Keywords: estrogen receptor, lbd, grip peptide, hormone-growth factor receptor complex, hormone/growth factor receptor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 62736.16

Authors

Rajan, S.S.,Hsieh, R.W.,Sharma, S.K.,Greene, G.L. (deposition date: 2005-09-16, release date: 2006-05-09, Last modification date: 2023-08-23)

• Primary citation: Hsieh, R.W.,Rajan, S.S.,Sharma, S.K.,Guo, Y.,Desombre, E.R.,Mrksich, M.,Greene, G.L.; Identification of ligands with bicyclic scaffolds provides insights into mechanisms of estrogen receptor subtype selectivity.; J.Biol.Chem., 281:17909-17919, 2006; PubMed: 16648639; DOI: 10.1074/jbc.M513684200

Experimental method

X-RAY DIFFRACTION (1.8 Å)