2ARP

Activin A in complex with Fs12 fragment of follistatin

Summary for 2ARP

• Entry DOI: 10.2210/pdb2arp/pdb
• Related: 2ARV
• Descriptor: Inhibin beta A chain, Follistatin, NICKEL (II) ION, ... (6 entities in total)
• Functional Keywords: cystine knot, disulfide rich, egf domain, kazal domain, protein complex, hormone-growth factor complex, hormone/growth factor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P08476 P21674
• Total number of polymer chains: 2
• Total formula weight: 30381.82

Authors

Harrington, A.E.,Morris-Triggs, S.A.,Ruotolo, B.T.,Robinson, C.V.,Ohnuma, S.,Hyvonen, M. (deposition date: 2005-08-21, release date: 2006-03-07, Last modification date: 2023-08-23)

• Primary citation: Harrington, A.E.,Morris-Triggs, S.A.,Ruotolo, B.T.,Robinson, C.V.,Ohnuma, S.,Hyvonen, M.; Structural basis for the inhibition of activin signalling by follistatin; Embo J., 25:1035-1045, 2006; PubMed: 16482217; DOI: 10.1038/sj.emboj.7601000

Experimental method

X-RAY DIFFRACTION (2 Å)