2AOA

Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain

Summary for 2AOA

Entry DOI	10.2210/pdb2aoa/pdb
Descriptor	Growth factor receptor-bound protein 2, 2-(4-((9S,10S,14S,Z)-18-(2-AMINO-2-OXOETHYL)-9-(CARBOXYMETHYL)-14-(NAPHTHALEN-1-YLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL)PHENYL)MALONIC ACID, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, ... (4 entities in total)
Functional Keywords	grb2 sh2, domain-swapped, peptide mimetic, transferase
Biological source	Homo sapiens (human)
Cellular location	Nucleus : P62993
Total number of polymer chains	2
Total formula weight	25741.17
Authors	Phan, J.,Shi, Z.D.,Burke, T.R.,Waugh, D.S. (deposition date: 2005-08-12, release date: 2005-10-04, Last modification date: 2024-02-14)
Primary citation	Phan, J.,Shi, Z.D.,Burke, T.R.,Waugh, D.S. Crystal Structures of a High-affinity Macrocyclic Peptide Mimetic in Complex with the Grb2 SH2 Domain. J.Mol.Biol., 353:104-115, 2005 Cited by PubMed: 16165154 DOI: 10.1016/j.jmb.2005.08.037 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.99 Å)

Structure validation