2ANL

X-ray crystal structure of the aspartic protease plasmepsin 4 from the malarial parasite plasmodium malariae bound to an allophenylnorstatine based inhibitor

Summary for 2ANL

Entry DOI	10.2210/pdb2anl/pdb
Related PRD ID	PRD_000566
Descriptor	plasmepsin IV, (4R)-3-{(2S,3S)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-phenylbutanoyl}-5,5-dimethyl-N-(2-methylbenzyl)-1,3-thiazolidine-4-carboxamide (3 entities in total)
Functional Keywords	plasmodium parasite, plasmepsin 4, aspartic protease, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Plasmodium malariae
Total number of polymer chains	2
Total formula weight	75413.09
Authors	Clemente, J.C.,Govindasamy, L.,Madabushi, A.,Fisher, S.Z.,Moose, R.E.,Yowell, C.A.,Hidaka, K.,Kimura, T.,Hayashi, Y.,Kiso, Y.,Agbandje-McKenna, M.,Dame, J.B.,Dunn, B.M.,McKenna, R. (deposition date: 2005-08-11, release date: 2006-04-04, Last modification date: 2024-04-03)
Primary citation	Clemente, J.C.,Govindasamy, L.,Madabushi, A.,Fisher, S.Z.,Moose, R.E.,Yowell, C.A.,Hidaka, K.,Kimura, T.,Hayashi, Y.,Kiso, Y.,Agbandje-McKenna, M.,Dame, J.B.,Dunn, B.M.,McKenna, R. Structure of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae bound to an allophenylnorstatine-based inhibitor. Acta Crystallogr.,Sect.D, 62:246-252, 2006 Cited by PubMed: 16510971 DOI: 10.1107/S0907444905041260 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.3 Å)

Structure validation