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2AM9

Crystal structure of human androgen receptor ligand binding domain in complex with testosterone

Summary for 2AM9
Entry DOI10.2210/pdb2am9/pdb
Related2AMA 2AMB
DescriptorAndrogen receptor, SULFATE ION, TESTOSTERONE, ... (6 entities in total)
Functional Keywordsnuclear receptor, androgen receptor, ligand binding domain, testosterone, agonist, hormone-growth factor receptor complex, hormone/growth factor receptor
Biological sourceHomo sapiens (human)
Cellular locationNucleus: P10275
Total number of polymer chains1
Total formula weight31627.02
Authors
Pereira de Jesus-Tran, K.,Cote, P.-L.,Cantin, L.,Blanchet, J.,Labrie, F.,Breton, R. (deposition date: 2005-08-09, release date: 2006-05-16, Last modification date: 2011-07-13)
Primary citationPereira de Jesus-Tran, K.,Cote, P.-L.,Cantin, L.,Blanchet, J.,Labrie, F.,Breton, R.
Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity.
Protein Sci., 15:987-999, 2006
Cited by
PubMed: 16641486
DOI: 10.1110/ps.051905906
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.64 Å)
Structure validation

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