2YHO

The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor

Summary for 2YHO

• Entry DOI: 10.2210/pdb2yho/pdb
• Related: 2C4P 2YHN
• Descriptor: E3 UBIQUITIN-PROTEIN LIGASE MYLIP, UBIQUITIN-CONJUGATING ENZYME E2 D1, ZINC ION, ... (5 entities in total)
• Functional Keywords: ligase, e2 ligase-e3 ligase complex, ring zinc-finger, ubl conjugation pathway
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Cytoplasm (Probable): Q8WY64; Cytoplasm: P51668
• Total number of polymer chains: 8
• Total formula weight: 103500.87

Authors

Fairall, L.,Goult, B.T.,Millard, C.J.,Tontonoz, P.,Schwabe, J.W.R. (deposition date: 2011-05-04, release date: 2011-06-29, Last modification date: 2023-12-20)

• Primary citation: Zhang, L.,Fairall, L.,Goult, B.T.,Calkin, A.C.,Hong, C.,Millard, C.J.,Tontonoz, P.,Schwabe, J.W.; The Idol-Ube2D Complex Mediates Sterol-Dependent Degradation of the Ldl Receptor.; Genes Dev., 25:1262-, 2011; PubMed: 21685362; DOI: 10.1101/GAD.2056211

Experimental method

X-RAY DIFFRACTION (2.1 Å)