2Y1X

CRYSTAL STRUCTURE OF COACTIVATOR ASSOCIATED ARGININE METHYLTRANSFERASE 1 (CARM1) IN COMPLEX WITH SINEFUNGIN AND INDOLE INHIBITOR

2Y1X の概要

• エントリーDOI: 10.2210/pdb2y1x/pdb
• 関連するPDBエントリー: 2Y1W
• 分子名称: HISTONE-ARGININE METHYLTRANSFERASE CARM1, S-ADENOSYL-L-HOMOCYSTEINE, N-(3-{5-[5-(1H-INDOL-4-YL)-1,3,4-OXADIAZOL-2-YL]-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL}BENZYL)-L-ALANINAMIDE, ... (5 entities in total)
• 機能のキーワード: histone modification, transferase
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Nucleus: Q86X55
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 161588.98

構造登録者

Sack, J.S.,Thieffine, S.,Bandiera, T.,Fasolini, M.,Duke, G.J.,Jayaraman, L.,Kish, K.F.,Klei, H.E.,Purandare, A.V.,Rosettani, P.,Troiani, S.,Xie, D.,Bertrand, J.A. (登録日: 2010-12-10, 公開日: 2011-03-23, 最終更新日: 2011-07-13)

• 主引用文献: Sack, J.S.,Thieffine, S.,Bandiera, T.,Fasolini, M.,Duke, G.J.,Jayaraman, L.,Kish, K.F.,Klei, H.E.,Purandare, A.V.,Rosettani, P.,Troiani, S.,Xie, D.,Bertrand, J.A.; Structural Basis for Carm1 Inhibition by Indole and Pyrazole Inhibitors; Biochem.J., 436:331-, 2011; PubMed: 21410432; DOI: 10.1042/BJ20102161

実験手法

X-RAY DIFFRACTION (2.4 Å)