2XYR

Crystal structure of the nsp16 nsp10 SARS coronavirus complex

Summary for 2XYR

• Entry DOI: 10.2210/pdb2xyr/pdb
• Descriptor: PUTATIVE 2'-O-METHYL TRANSFERASE, NON-STRUCTURAL PROTEIN 10, SODIUM ION, ... (8 entities in total)
• Functional Keywords: transferase-viral protein complex, rossmann fold, transferase/viral protein
• Biological source: SARS CORONAVIRUS; More
• Cellular location: Papain-like proteinase: Host membrane; Multi-pass membrane protein. Non-structural protein 4: Host membrane; Multi-pass membrane protein. Non-structural protein 6: Host membrane ; Multi-pass membrane protein . Non-structural protein 7: Host cytoplasm, host perinuclear region . Non-structural protein 8: Host cytoplasm, host perinuclear region . Non-structural protein 9: Host cytoplasm, host perinuclear region . Non-structural protein 10: Host cytoplasm, host perinuclear region . Helicase: Host endoplasmic reticulum-Golgi intermediate compartment . Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region : P0C6X7 P0C6X7
• Total number of polymer chains: 2
• Total formula weight: 46655.40

Authors

Decroly, E.,Debarnot, C.,Ferron, F.,Bouvet, M.,Coutard, B.,Imbert, I.,Gluais, L.,Papageorgiou, N.,Ortiz-Lombardia, M.,Lescar, J.,Canard, B. (deposition date: 2010-11-18, release date: 2011-10-26, Last modification date: 2023-12-20)

• Primary citation: Decroly, E.,Debarnot, C.,Ferron, F.,Bouvet, M.,Coutard, B.,Imbert, I.,Gluais, L.,Papageorgiou, N.,Sharff, A.,Bricogne, G.,Ortiz-Lombardia, M.,Lescar, J.,Canard, B.; Crystal Structure and Functional Analysis of the Sars-Coronavirus RNA CAP 2'-O-Methyltransferase Nsp10/Nsp16 Complex.; Plos Pathog., 7:2059-, 2011; PubMed: 21637813; DOI: 10.1371/JOURNAL.PPAT.1002059

Experimental method

X-RAY DIFFRACTION (2.5 Å)