2XB7

Structure of Human Anaplastic Lymphoma Kinase in complex with NVP- TAE684

2XB7 の概要

• エントリーDOI: 10.2210/pdb2xb7/pdb
• 分子名称: ALK TYROSINE KINASE RECEPTOR, 5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL)PIPERIDIN-1-YL]PHENYL]-N'-(2-PROPAN-2-YLSULFONYLPHENYL)PYRIMIDINE-2,4-DIAMINE (3 entities in total)
• 機能のキーワード: atp-binding, receptor, transferase
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: Q9UM73
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35948.82

構造登録者

Bossi, R.T.,Saccardo, M.B.,Ardini, E.,Menichincheri, M.,Rusconi, L.,Magnaghi, P.,Orsini, P.,Fogliatto, G.,Bertrand, J.A. (登録日: 2010-04-08, 公開日: 2010-07-28, 最終更新日: 2011-07-13)

• 主引用文献: Bossi, R.T.,Saccardo, M.B.,Ardini, E.,Menichincheri, M.,Rusconi, L.,Magnaghi, P.,Orsini, P.,Avanzi, N.,Borgia, A.L.,Nesi, M.,Bandiera, T.,Fogliatto, G.,Bertrand, J.A.; Crystal Structures of Anaplastic Lymphoma Kinase in Complex with ATP Competitive Inhibitors.; Biochemistry, 49:6813-, 2010; PubMed: 20695522; DOI: 10.1021/BI1005514

実験手法

X-RAY DIFFRACTION (2.5 Å)