2X6E

Aurora-A bound to an inhibitor

Summary for 2X6E

Entry DOI	10.2210/pdb2x6e/pdb
Related	1MQ4 1MUO 1OL5 1OL6 1OL7 2BMC 2C6D 2C6E 2J4Z 2J50 2W1C 2W1D 2W1E 2W1F 2W1G 2WQE 2WTV 2WTW 2X6D
Descriptor	SERINE/THREONINE-PROTEIN KINASE 6, 6-BROMO-7-{4-[(5-METHYLISOXAZOL-3-YL)METHYL]PIPERAZIN-1-YL}-2-[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]-1H-IMIDAZO[4,5-B]PYRIDINE (2 entities in total)
Functional Keywords	transferase, mitosis, cell cycle
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : O14965
Total number of polymer chains	1
Total formula weight	33500.26
Authors	Kosmopoulou, M.,Bayliss, R. (deposition date: 2010-02-17, release date: 2010-07-07, Last modification date: 2023-12-20)
Primary citation	Bavetsias, V.,Large, J.M.,Sun, C.,Bouloc, N.,Kosmopoulou, M.,Matteucci, M.,Wilsher, N.E.,Martins, V.,Reynisson, J.,Atrash, B.,Faisal, A.,Urban, F.,Valenti, M.,de Haven Brandon, A.,Box, G.,Raynaud, F.I.,Workman, P.,Eccles, S.A.,Bayliss, R.,Blagg, J.,Linardopoulos, S.,McDonald, E. Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate. J. Med. Chem., 53:5213-5228, 2010 Cited by PubMed: 20565112 DOI: 10.1021/jm100262j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.35 Å)

Structure validation