2X6D

Aurora-A bound to an inhibitor

2X6D の概要

• エントリーDOI: 10.2210/pdb2x6d/pdb
• 関連するPDBエントリー: 1MQ4 1MUO 1OL5 1OL6 1OL7 2BMC 2C6D 2C6E 2J4Z 2J50 2W1C 2W1D 2W1E 2W1F 2W1G 2WQE 2WTV 2WTW 2X6E
• 分子名称: SERINE/THREONINE-PROTEIN KINASE 6, SULFATE ION, 6-BROMO-7-[4-(4-CHLOROBENZYL)PIPERAZIN-1-YL]-2-[4-(MORPHOLIN-4-YLMETHYL)PHENYL]-3H-IMIDAZO[4,5-B]PYRIDINE, ... (4 entities in total)
• 機能のキーワード: transferase, mitosis
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33722.84

構造登録者

Kosmopoulou, M.,Bayliss, R. (登録日: 2010-02-17, 公開日: 2010-07-07, 最終更新日: 2023-12-20)

• 主引用文献: Bavetsias, V.,Large, J.M.,Sun, C.,Bouloc, N.,Kosmopoulou, M.,Matteucci, M.,Wilsher, N.E.,Martins, V.,Reynisson, J.,Atrash, B.,Faisal, A.,Urban, F.,Valenti, M.,de Haven Brandon, A.,Box, G.,Raynaud, F.I.,Workman, P.,Eccles, S.A.,Bayliss, R.,Blagg, J.,Linardopoulos, S.,McDonald, E.; Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate.; J. Med. Chem., 53:5213-5228, 2010; PubMed: 20565112; DOI: 10.1021/jm100262j

実験手法

X-RAY DIFFRACTION (2.796 Å)