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2X38

The crystal structure of the murine class IA PI 3-kinase p110delta in complex with IC87114.

Replaces:  2WXE
Summary for 2X38
Entry DOI10.2210/pdb2x38/pdb
DescriptorPHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM, 2-[(6-AMINO-9H-PURIN-9-YL)METHYL]-5-METHYL-3-(2-METHYLPHENYL)QUINAZOLIN-4(3H)-ONE (3 entities in total)
Functional Keywordsphosphoinositide 3-kinase, isoform-specific inhibitors, cancer, transferase
Biological sourceMUS MUSCULUS (MOUSE)
Total number of polymer chains1
Total formula weight108221.10
Authors
Primary citationBerndt, A.,Miller, S.,Williams, O.,Lee, D.D.,Houseman, B.T.,Pacold, J.I.,Gorrec, F.,Hon, W.-C.,Liu, Y.,Rommel, C.,Gaillard, P.,Ruckle, T.,Schwarz, M.K.,Shokat, K.M.,Shaw, J.P.,Williams, R.L.
The P110D Structure: Mechanisms for Selectivity and Potency of New Pi(3)K Inhibitors
Nat.Chem.Biol., 6:117-, 2010
Cited by
PubMed: 20081827
DOI: 10.1038/NCHEMBIO.293
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

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