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2WMX

Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors

Summary for 2WMX
Entry DOI10.2210/pdb2wmx/pdb
Related1IA8 1NVQ 1NVR 1NVS 1ZLT 1ZYS 2AYP 2BR1 2BRB 2BRG 2BRH 2BRM 2BRN 2BRO 2C3J 2C3K 2C3L 2CGU 2CGV 2CGW 2CGX 2WMQ 2WMR 2WMS 2WMT 2WMU 2WMV 2WMW
DescriptorSERINE/THREONINE-PROTEIN KINASE CHK1, 1-[(2S)-4-(5-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl)morpholin-2-yl]methanamine (3 entities in total)
Functional Keywordsserine/threonine-protein kinase, polymorphism, phosphoprotein, ubl conjugation, isopeptide bond, checkpoint kinase, nucleotide-binding, serine/threonine kinase, dna damage, dna repair, atp-binding, transferase, chk1, kinase, nucleus, cytoplasm, cell cycle
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus: O14757
Total number of polymer chains1
Total formula weight33352.35
Authors
Primary citationMatthews, T.P.,Klair, S.,Burns, S.,Boxall, K.,Cherry, M.,Fisher, M.,Westwood, I.M.,Walton, M.I.,Mchardy, T.,Cheung, K.-M.J.,Van Montfort, R.,Williams, D.,Aherne, G.W.,Garrett, M.D.,Reader, J.,Collins, I.
Identification of Inhibitors of Checkpoint Kinase 1 Through Template Screening.
J.Med.Chem., 52:4810-, 2009
Cited by
PubMed: 19572549
DOI: 10.1021/JM900314J
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.45 Å)
Structure validation

217705

건을2024-03-27부터공개중

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