2V0C

LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A SULPHAMOYL ANALOGUE OF LEUCYL-ADENYLATE In the synthetic site and an adduct of AMP with 5-Fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2690) in the editing site

2V0C の概要

• エントリーDOI: 10.2210/pdb2v0c/pdb
• 関連するPDBエントリー: 1H3N 1OBC 1OBH 2BTE 2BYT
• 分子名称: AMINOACYL-TRNA SYNTHETASE, LEUCINE, [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDRO-2-FURANYL]METHYL SULFAMATE, ... (7 entities in total)
• 機能のキーワード: ligase, nucleotide-binding, protein biosynthesis, clss i aminoacyl- trna synthetase, atp + l-leucine + trna (leu) gives amp + ppi + l-leucyl-trna(leu), aminoacyl-trna synthetase, zinc, atp-binding, metal-binding
• 由来する生物種: THERMUS THERMOPHILUS
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 102566.67

構造登録者

Rock, F.,Mao, W.,Yaremchuk, A.,Tukalo, M.,Crepin, T.,Zhou, H.,Zhang, Y.,Hernandez, V.,Akama, T.,Baker, S.,Plattner, J.,Shapiro, L.,Martinis, S.A.,Benkovic, S.J.,Cusack, S.,Alley, M.R.K. (登録日: 2007-05-14, 公開日: 2007-07-03, 最終更新日: 2023-12-13)

• 主引用文献: Rock, F.,Mao, W.,Yaremchuk, A.,Tukalo, M.,Crepin, T.,Zhou, H.,Zhang, Y.,Hernandez, V.,Akama, T.,Baker, S.,Plattner, J.,Shapiro, L.,Martinis, S.A.,Benkovic, S.J.,Cusack, S.,Alley, M.R.K.; An Antifungal Agent Inhibits an Aminoacyl-tRNA Synthetase by Trapping tRNA in the Editing Site.; Science, 316:1759-, 2007; PubMed: 17588934; DOI: 10.1126/SCIENCE.1142189

実験手法

X-RAY DIFFRACTION (1.85 Å)