2QUG

Crystal structure of alpha-1-antitrypsin, crystal form A

Summary for 2QUG

Entry DOI	10.2210/pdb2qug/pdb
Descriptor	Alpha-1-antitrypsin (2 entities in total)
Functional Keywords	antitrypsin, polymerisation, protein aggregation, protein unfolding, serpin, acute phase, disease mutation, glycoprotein, protease inhibitor, secreted, serine protease inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Secreted. Short peptide from AAT: Secreted, extracellular space, extracellular matrix: P01009
Total number of polymer chains	1
Total formula weight	44410.36
Authors	Hansen, G.,Morton, C.J.,Pearce, M.C.,Feil, S.C.,Adams, J.J.,Parker, M.W.,Bottomley, S.P. (deposition date: 2007-08-05, release date: 2008-08-12, Last modification date: 2011-07-13)
Primary citation	Pearce, M.C.,Morton, C.J.,Feil, S.C.,Hansen, G.,Adams, J.J.,Parker, M.W.,Bottomley, S.P. Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding. Protein Sci., 17:2127-2133, 2008 Cited by PubMed: 18780818 DOI: 10.1110/ps.037234.108 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation