2Q6F

Crystal structure of infectious bronchitis virus (IBV) main protease in complex with a Michael acceptor inhibitor N3

Summary for 2Q6F

Entry DOI	10.2210/pdb2q6f/pdb
Related	2Q6D 2Q6G
Related PRD ID	PRD_002214
Descriptor	Infectious bronchitis virus (IBV) main protease, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE (3 entities in total)
Functional Keywords	coronavirus; ibv; main protease; 3c-like proteinase; michael acceptor inhibitor, hydrolase
Biological source	Infectious bronchitis virus More
Total number of polymer chains	4
Total formula weight	68633.48
Authors	Xue, X.Y.,Yang, H.T.,Xue, F.,Bartlam, M.,Rao, Z.H. (deposition date: 2007-06-05, release date: 2008-02-12, Last modification date: 2023-11-15)
Primary citation	Xue, X.,Yu, H.,Yang, H.,Xue, F.,Wu, Z.,Shen, W.,Li, J.,Zhou, Z.,Ding, Y.,Zhao, Q.,Zhang, X.C.,Liao, M.,Bartlam, M.,Rao, Z. Structures of two coronavirus main proteases: implications for substrate binding and antiviral drug design. J.Virol., 82:2515-2527, 2008 Cited by PubMed: 18094151 DOI: 10.1128/JVI.02114-07 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation