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2PVF

Crystal Structure of Tyrosine Phosphorylated Activated FGF Receptor 2 (FGFR2) Kinase Domain in Complex with ATP Analog and Substrate Peptide

Summary for 2PVF
Entry DOI10.2210/pdb2pvf/pdb
Related2PSQ 2PVY 2PWL 2PY3 2PZ5 2PZP 2PZR 2Q0B
DescriptorFibroblast growth factor receptor 2, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (5 entities in total)
Functional Keywordskinase domain fold consisting of n- and c-lobes, transferase
Biological sourceHomo sapiens (human)
More
Cellular locationCell membrane; Single-pass type I membrane protein. Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted: P21802 P21802
Total number of polymer chains2
Total formula weight40871.48
Authors
Chen, H.,Mohammadi, M. (deposition date: 2007-05-09, release date: 2007-09-25, Last modification date: 2023-11-15)
Primary citationChen, H.,Ma, J.,Li, W.,Eliseenkova, A.V.,Xu, C.,Neubert, T.A.,Miller, W.T.,Mohammadi, M.
A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27:717-730, 2007
Cited by
PubMed: 17803937
DOI: 10.1016/j.molcel.2007.06.028
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

217705

건을2024-03-27부터공개중

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