2PPB

Crystal structure of the T. thermophilus RNAP polymerase elongation complex with the ntp substrate analog and antibiotic streptolydigin

Summary for 2PPB

• Entry DOI: 10.2210/pdb2ppb/pdb
• Related: 2O5I 2O5J
• Descriptor: DNA (5'-D(P*CP*CP*CP*TP*GP*TP*CP*TP*GP*GP*CP*GP*TP*TP*CP*GP*CP*GP*CP*GP*CP*CP*G)-3'), MAGNESIUM ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... (12 entities in total)
• Functional Keywords: rna polymerase, elongation complex, template dna, non-template dna, rna transcript, ntp substrate, antibiotic streptolydigin, transferase-dna-rna complex, transferase/dna/rna
• Biological source: Thermus thermophilus; More
• Total number of polymer chains: 16
• Total formula weight: 791748.70

Authors

Vassylyev, D.G.,Vassylyeva, M.N.,Artsimovitch, I.,Landick, R. (deposition date: 2007-04-28, release date: 2007-07-17, Last modification date: 2023-08-30)

• Primary citation: Vassylyev, D.G.,Vassylyeva, M.N.,Zhang, J.,Palangat, M.,Artsimovitch, I.,Landick, R.; Structural basis for substrate loading in bacterial RNA polymerase.; Nature, 448:163-168, 2007; PubMed: 17581591; DOI: 10.1038/nature05931

Experimental method

X-RAY DIFFRACTION (3 Å)