2O7N

CD11A (LFA1) I-domain complexed with 7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-5-oxo-2,3,5,7A-tetrahydro-1H-pyrrolo[1,2-A]pyrrole-7-carbonitrile

Summary for 2O7N

• Entry DOI: 10.2210/pdb2o7n/pdb
• Related: 2ICA
• Descriptor: Integrin alpha-L, 7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-5-oxo-2,3,5,7A-tetrahydro-1H-pyrrolo[1,2-A]pyrrole-7-carbonitrile (3 entities in total)
• Functional Keywords: inhibitor, protein-ligand complex, cell adhesion
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane ; Single-pass type I membrane protein : P20701
• Total number of polymer chains: 1
• Total formula weight: 21344.26

Authors

Sheriff, S. (deposition date: 2006-12-11, release date: 2007-03-20, Last modification date: 2023-08-30)

• Primary citation: Dodd, D.S.,Sheriff, S.,Chang, C.J.,Stetsko, D.K.,Phillips, L.M.,Zhang, Y.,Launay, M.,Potin, D.,Vaccaro, W.,Poss, M.A.,McKinnon, M.,Barrish, J.C.,Suchard, S.J.,Murali Dhar, T.G.; Design of LFA-1 antagonists based on a 2,3-dihydro-1H-pyrrolizin-5(7aH)-one scaffold.; Bioorg.Med.Chem.Lett., 17:1908-1911, 2007; PubMed: 17291752; DOI: 10.1016/j.bmcl.2007.01.036

Experimental method

X-RAY DIFFRACTION (1.75 Å)