2O3U

Structural Basis for Formation and Hydrolysis of Calcium Messenger Cyclic ADP-ribose by Human CD38

Summary for 2O3U

Entry DOI	10.2210/pdb2o3u/pdb
Related	1YH3 2O3Q 2O3R 2O3S 2O3T
Descriptor	ADP-ribosyl cyclase 1, 3-(AMINOCARBONYL)-1-[(2R,3R,4S,5R)-5-({[(S)-{[(S)-{[(2R,3S,4R,5R)-5-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)-3,4-DIHYD ROXYTETRAHYDROFURAN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]OXY}METHYL)-3,4-DIHYDROXYTETRAHYDROFURAN-2- YL]PYRIDINIUM (3 entities in total)
Functional Keywords	human cd38 e226q mutant, the catalytic pocket, ngd binding and hydrolysis, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type II membrane protein: P28907
Total number of polymer chains	2
Total formula weight	62119.68
Authors	Liu, Q.,Kriksunov, I.A.,Graeff, R.,Lee, H.C.,Hao, Q. (deposition date: 2006-12-01, release date: 2006-12-19, Last modification date: 2023-08-30)
Primary citation	Liu, Q.,Kriksunov, I.A.,Graeff, R.,Lee, H.C.,Hao, Q. Structural basis for formation and hydrolysis of the calcium messenger cyclic ADP-ribose by human CD38 J.Biol.Chem., 282:5853-5861, 2007 Cited by PubMed: 17182614 DOI: 10.1074/jbc.M609093200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.11 Å)

Structure validation