2NNK

Crystal structure analysis of HIV-1 protease mutant I84V with a inhibitor saquinavir

Summary for 2NNK

Entry DOI	10.2210/pdb2nnk/pdb
Related	2NMW 2NMY 2NMZ 2NNP
Related PRD ID	PRD_000454
Descriptor	PROTEASE, SODIUM ION, CHLORIDE ION, ... (7 entities in total)
Functional Keywords	hiv-1 protease, mutant, i84v, dimer, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus 1
Cellular location	Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04587
Total number of polymer chains	2
Total formula weight	22520.72
Authors	Tie, Y.,Kovalevsky, A.Y.,Boross, P.,Wang, Y.F.,Ghosh, A.K.,Tozser, J.,Harrison, R.W.,Weber, I.T. (deposition date: 2006-10-24, release date: 2007-03-13, Last modification date: 2023-12-27)
Primary citation	Tie, Y.,Kovalevsky, A.Y.,Boross, P.,Wang, Y.F.,Ghosh, A.K.,Tozser, J.,Harrison, R.W.,Weber, I.T. Atomic resolution crystal structures of HIV-1 protease and mutants V82A and I84V with saquinavir. Proteins, 67:232-242, 2007 Cited by PubMed: 17243183 DOI: 10.1002/prot.21304 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.25 Å)

Structure validation