2LI8

The solution structure of the Lin28-ZnF domains bound to AGGAGAU of pre-let-7 miRNA

Summary for 2LI8

• Entry DOI: 10.2210/pdb2li8/pdb
• Related: 2CQF
• NMR Information: BMRB: 17883
• Descriptor: Protein lin-28 homolog A, RNA (5'-R(*AP*GP*GP*AP*GP*AP*U)-3'), ZINC ION (3 entities in total)
• Functional Keywords: zinc finger, micro rna, transcription-rna complex, transcription/rna
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q9H9Z2
• Total number of polymer chains: 2
• Total formula weight: 10448.64

Authors

Allain, F.H.-T.,Loughlin, F.E. (deposition date: 2011-08-25, release date: 2011-12-07, Last modification date: 2012-01-25)

• Primary citation: Loughlin, F.E.,Gebert, L.F.,Towbin, H.,Brunschweiger, A.,Hall, J.,Allain, F.H.; Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28.; Nat.Struct.Mol.Biol., 19:84-89, 2011; PubMed: 22157959; DOI: 10.1038/nsmb.2202

Experimental method

SOLUTION NMR