2JFA

ESTROGEN RECEPTOR ALPHA LBD IN COMPLEX WITH AN AFFINITY-SELECTED COREPRESSOR PEPTIDE

Summary for 2JFA

Entry DOI	10.2210/pdb2jfa/pdb
Related	1A52 1AKF 1ERE 1ERR 1G50 1GWQ 1GWR 1HCP 1HCQ 1L2I 1PCG 1QKT 1QKU 1R5K 1SJ0 1UOM 1X7E 1X7R 1XP1 1XP6 1XP9 1XPC 1XQC 1YIM 1YIN 1ZKY 2AYR 2B1V 2BJ4 2FAI 2JF9 3ERD 3ERT
Descriptor	ESTROGEN RECEPTOR, COREPRESSOR PEPTIDE, RALOXIFENE, ... (6 entities in total)
Functional Keywords	transcription, transcription factor, phage display, metal-binding, corepressor, lipid-binding, transcription regulation, ligand-binding domain (lbd), nuclear protein, phosphorylation, steroid- binding, receptor, zinc-finger, dna-binding, nuclear receptor, peptide antagonist
Biological source	HOMO SAPIENS (HUMAN) More
Cellular location	Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372 P03372
Total number of polymer chains	4
Total formula weight	62540.82
Authors	Heldring, N.,Pawson, T.,McDonnell, D.,Treuter, E.,Gustafsson, J.A.,Pike, A.C.W. (deposition date: 2007-01-29, release date: 2007-02-20, Last modification date: 2023-12-13)
Primary citation	Heldring, N.,Pawson, T.,Mcdonnell, D.,Treuter, E.,Gustafsson, J.A.,Pike, A.C.W. Structural Insights Into Corepressor Recognition by Antagonist-Bound Estrogen Receptors. J.Biol.Chem., 282:10449-, 2007 Cited by PubMed: 17283072 DOI: 10.1074/JBC.M611424200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation