2J2I

Crystal Structure of the humab PIM1 in complex with LY333531

Summary for 2J2I

• Entry DOI: 10.2210/pdb2j2i/pdb
• Related: 1XQZ 1XR1 1XWS 1YHS 1YI3 1YI4 1YWV 1YXS 1YXT 1YXU 1YXV 1YXX 2BIK 2BIL 2BZH 2BZI 2BZJ 2BZK 2C3I
• Descriptor: PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1, SULFATE ION, (9R)-9-[(DIMETHYLAMINO)METHYL]-6,7,10,11-TETRAHYDRO-9H,18H-5,21:12,17-DIMETHENODIBENZO[E,K]PYRROLO[3,4-H][1,4,13]OXADIA ZACYCLOHEXADECINE-18,20-DIONE, ... (4 entities in total)
• Functional Keywords: transferase, nucleotide-binding, alternative initiation, serine/threonine-protein kinase, atp-binding, metal-binding, proto-oncogene, kinase, cancer, leukemia, manganese, nuclear protein, proto- oncogene, phosphorylation
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 36068.03

Authors

Debreczeni, J.E.,Bullock, A.N.,von Delft, F.,Sundstrom, M.,Arrowsmith, C.,Edwards, A.,Weigelt, J.,Knapp, S. (deposition date: 2006-08-16, release date: 2007-02-13, Last modification date: 2023-12-13)

• Primary citation: Fedorov, O.,Marsden, B.,Pogacic, V.,Rellos, P.,Muller, S.,Bullock, A.N.,Schwaller, J.,Sundstrom, M.,Knapp, S.; A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.; Proc. Natl. Acad. Sci. U.S.A., 104:20523-20528, 2007; PubMed: 18077363; DOI: 10.1073/pnas.0708800104

Experimental method

X-RAY DIFFRACTION (1.9 Å)