2IT4

X ray structure of the complex between Carbonic Anhydrase I and the phosphonate antiviral drug foscarnet

Summary for 2IT4

Entry DOI	10.2210/pdb2it4/pdb
Descriptor	Carbonic anhydrase 1, ZINC ION, PHOSPHONOFORMIC ACID, ... (4 entities in total)
Functional Keywords	carbonic anhydrase, antiviral, crystal stucture, lyase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P00915
Total number of polymer chains	2
Total formula weight	57066.08
Authors	Temperini, C.,Innocenti, A.,Guerri, A.,Scozzafava, A.,Supuran, C.T. (deposition date: 2006-10-19, release date: 2007-09-11, Last modification date: 2023-08-30)
Primary citation	Temperini, C.,Innocenti, A.,Guerri, A.,Scozzafava, A.,Rusconi, S.,Supuran, C.T. Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I. Bioorg.Med.Chem.Lett., 17:2210-2215, 2007 Cited by PubMed: 17314045 DOI: 10.1016/j.bmcl.2007.01.113 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation