2IJD

Crystal Structure of the Poliovirus Precursor Protein 3CD

Summary for 2IJD

• Entry DOI: 10.2210/pdb2ijd/pdb
• Descriptor: Picornain 3C, RNA-directed RNA polymerase, ZINC ION, SULFATE ION, ... (4 entities in total)
• Functional Keywords: rna polymerase, rna-dependent rna polymerase, poliovirus, picornavirus, protease, hydrolase, transferase
• Biological source: Human poliovirus 1
• Cellular location: Protein VP2: Virion. Protein VP3: Virion. Protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 2C: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3A: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3B: Virion (Potential). Picornain 3C: Host cytoplasm (Potential). RNA-directed RNA polymerase 3D-POL: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential): P03300
• Total number of polymer chains: 2
• Total formula weight: 144917.53

Authors

Marcotte, L.L.,Gohara, D.W.,Filman, D.J.,Hogle, J.M. (deposition date: 2006-09-29, release date: 2007-02-13, Last modification date: 2023-08-30)

• Primary citation: Marcotte, L.L.,Wass, A.B.,Gohara, D.W.,Pathak, H.B.,Arnold, J.J.,Filman, D.J.,Cameron, C.E.,Hogle, J.M.; Crystal structure of poliovirus 3CD: virally-encoded protease and precursor to the RNA-dependent RNA polymerase.; J.Virol., 81:3583-3596, 2007; PubMed: 17251299; DOI: 10.1128/JVI.02306-06

Experimental method

X-RAY DIFFRACTION (3.4 Å)