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2HX2

Bovine eNOS heme domain complexed with (4S)-N-{4-Amino-5-[(2-aminoethyl)-hydroxyamino]-pentyl}-N'-nitroguanidine

Summary for 2HX2
Entry DOI10.2210/pdb2hx2/pdb
Related2HX3 2HX4
DescriptorNitric-oxide synthase, CACODYLATE ION, ACETATE ION, ... (9 entities in total)
Functional Keywordsnitric oxide synthase, heme enzyme, inhibitor, oxidoreductase
Biological sourceBos taurus (cattle)
Cellular locationCell membrane: P29473
Total number of polymer chains2
Total formula weight96709.87
Authors
Igarashi, J.,Li, H.,Poulos, T.L. (deposition date: 2006-08-02, release date: 2007-04-24, Last modification date: 2024-02-14)
Primary citationSeo, J.,Igarashi, J.,Li, H.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B.
Structure-Based Design and Synthesis of N(omega)-Nitro-l-Arginine-Containing Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase. Displacement of the Heme Structural Water.
J.Med.Chem., 50:2089-2099, 2007
Cited by
PubMed: 17425297
DOI: 10.1021/jm061305c
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.95 Å)
Structure validation

217705

数据于2024-03-27公开中

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