2HL4

Crystal structure analysis of human carbonic anhydrase II in complex with a benzenesulfonamide derivative

Summary for 2HL4

Entry DOI	10.2210/pdb2hl4/pdb
Related	1CA2
Descriptor	Carbonic anhydrase 2, ZINC ION, CHLORIDE ION, ... (7 entities in total)
Functional Keywords	protein-inhibitor complex, lyase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	30006.87
Authors	Di Fiore, A.,Supuran, C.T.,Winum, J.-Y.,Montero, J.-L.,Pedone, C.,Scozzafava, A.,De Simone, G. (deposition date: 2006-07-06, release date: 2007-05-22, Last modification date: 2023-10-25)
Primary citation	Di Fiore, A.,Scozzafava, A.,Winum, J.-Y.,Montero, J.-L.,Pedone, C.,Supuran, C.T.,De Simone, G. Carbonic anhydrase inhibitors: binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties Bioorg.Med.Chem.Lett., 17:1726-1731, 2007 Cited by PubMed: 17251017 DOI: 10.1016/j.bmcl.2006.12.099 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation