2HL4
Crystal structure analysis of human carbonic anhydrase II in complex with a benzenesulfonamide derivative
Summary for 2HL4
Entry DOI | 10.2210/pdb2hl4/pdb |
Related | 1CA2 |
Descriptor | Carbonic anhydrase 2, ZINC ION, CHLORIDE ION, ... (7 entities in total) |
Functional Keywords | protein-inhibitor complex, lyase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 30006.87 |
Authors | Di Fiore, A.,Supuran, C.T.,Winum, J.-Y.,Montero, J.-L.,Pedone, C.,Scozzafava, A.,De Simone, G. (deposition date: 2006-07-06, release date: 2007-05-22, Last modification date: 2023-10-25) |
Primary citation | Di Fiore, A.,Scozzafava, A.,Winum, J.-Y.,Montero, J.-L.,Pedone, C.,Supuran, C.T.,De Simone, G. Carbonic anhydrase inhibitors: binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties Bioorg.Med.Chem.Lett., 17:1726-1731, 2007 Cited by PubMed: 17251017DOI: 10.1016/j.bmcl.2006.12.099 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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