2H67

NMR structure of human insulin mutant HIS-B5-ALA, HIS-B10-ASP PRO-B28-LYS, LYS-B29-PRO, 20 structures

Summary for 2H67

• Entry DOI: 10.2210/pdb2h67/pdb
• Descriptor: Insulin A chain, Insulin B chain (2 entities in total)
• Functional Keywords: hormone, human insulin, mutant, hormone-growth factor complex, hormone/growth factor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P01308 P01308
• Total number of polymer chains: 2
• Total formula weight: 5727.52

Authors

Hua, Q.X.,Liu, M.,Hu, S.Q.,Jia, W.,Arvan, P.,Weiss, M.A. (deposition date: 2006-05-30, release date: 2006-07-18, Last modification date: 2021-10-20)

• Primary citation: Hua, Q.X.,Liu, M.,Hu, S.Q.,Jia, W.,Arvan, P.,Weiss, M.A.; A Conserved Histidine in Insulin Is Required for the Foldability of Human Proinsulin: Structure and function of an Alab5 analog.; J.Biol.Chem., 281:24889-24899, 2006; PubMed: 16728398; DOI: 10.1074/jbc.M602617200

Experimental method

SOLUTION NMR