2G9X

Structure of Thr 160 phosphorylated CDK2/cyclin A in complex with the inhibitor NU6271

Summary for 2G9X

Entry DOI	10.2210/pdb2g9x/pdb
Descriptor	Cell division protein kinase 2, Cyclin-A2, 3-({2-[(4-{[6-(CYCLOHEXYLMETHOXY)-9H-PURIN-2-YL]AMINO}PHENYL)SULFONYL]ETHYL}AMINO)PROPAN-1-OL, ... (4 entities in total)
Functional Keywords	transferase, serine/threonine protein kinase, atp-binding, cell cycle, phosphorylation, transferase-cell cycle complex, transferase/cell cycle
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: P30274
Total number of polymer chains	4
Total formula weight	129269.56
Authors	Echalier, A.,Endicott, J.A.,Noble, M.E. (deposition date: 2006-03-07, release date: 2006-05-23, Last modification date: 2023-08-30)
Primary citation	Griffin, R.J.,Henderson, A.,Curtin, N.J.,Echalier, A.,Endicott, J.A.,Hardcastle, I.R.,Newell, D.R.,Noble, M.E.,Wang, L.Z.,Golding, B.T. Searching for Cyclin-Dependent Kinase Inhibitors Using a New Variant of the Cope Elimination. J.Am.Chem.Soc., 128:6012-6013, 2006 Cited by PubMed: 16669651 DOI: 10.1021/ja060595j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation