2G5T

Crystal structure of human dipeptidyl peptidase IV (DPPIV) complexed with cyanopyrrolidine (C5-pro-pro) inhibitor 21ag

2G5T の概要

• エントリーDOI: 10.2210/pdb2g5t/pdb
• 関連するPDBエントリー: 2G5P
• 分子名称: Dipeptidyl peptidase 4, 3-{[(2R,5S)-5-{[(2S)-2-(AMINOMETHYL)PYRROLIDIN-1-YL]CARBONYL}PYRROLIDIN-2-YL]METHOXY}-4-CHLOROBENZOIC ACID (3 entities in total)
• 機能のキーワード: serine peptidase, beta-propeller, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Dipeptidyl peptidase 4 soluble form: Secreted . Cell membrane ; Single- pass type II membrane protein: P27487
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 168886.53

構造登録者

Longenecker, K.L.,Fry, E.H.,Lake, M.R.,Solomon, L.R.,Pei, Z.,Li, X. (登録日: 2006-02-23, 公開日: 2006-07-04, 最終更新日: 2017-10-18)

• 主引用文献: Pei, Z.,Li, X.,Longenecker, K.,Von Geldern, T.W.,Wiedeman, P.E.,Lubben, T.H.,Zinker, B.A.,Stewart, K.,Ballaron, S.J.,Stashko, M.A.,Mika, A.K.,Beno, D.W.,Long, M.,Wells, H.,Kempf-Grote, A.J.,Madar, D.J.,McDermott, T.S.,Bhagavatula, L.,Fickes, M.G.,Pireh, D.,Solomon, L.R.,Lake, M.R.,Edalji, R.,Fry, E.H.,Sham, H.L.,Trevillyan, J.M.; Discovery, structure-activity relationship, and pharmacological evaluation of (5-substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as potent dipeptidyl peptidase IV inhibitors.; J.Med.Chem., 49:3520-3535, 2006; PubMed: 16759095; DOI: 10.1021/jm051283e

実験手法

X-RAY DIFFRACTION (2.3 Å)