2FO0

Organization of the SH3-SH2 Unit in Active and Inactive Forms of the c-Abl Tyrosine Kinase

2FO0 の概要

• エントリーDOI: 10.2210/pdb2fo0/pdb
• 分子名称: Proto-oncogene tyrosine-protein kinase ABL1 (1B ISOFORM), MYRISTIC ACID, 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, ... (5 entities in total)
• 機能のキーワード: n-terminal cap, autoinhibition, myristoylation, sh3-sh2 clamp, phosphoserine, transferase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 57292.21

構造登録者

Nagar, B.,Hantschel, O.,Seeliger, M.,Davies, J.M.,Weis, W.I.,Superti-Furga, G.,Kuriyan, J. (登録日: 2006-01-12, 公開日: 2006-03-21, 最終更新日: 2023-08-30)

• 主引用文献: Nagar, B.,Hantschel, O.,Seeliger, M.,Davies, J.M.,Weis, W.I.,Superti-Furga, G.,Kuriyan, J.; Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase.; Mol.Cell, 21:787-798, 2006; PubMed: 16543148; DOI: 10.1016/j.molcel.2006.01.035

実験手法

X-RAY DIFFRACTION (2.27 Å)