2YWP

Crystal Structure of CHK1 with a Urea Inhibitor

Replaces:  2FGA

Summary for 2YWP

• Entry DOI: 10.2210/pdb2ywp/pdb
• Related: 2AYP
• Descriptor: Serine/threonine-protein kinase Chk1, 1-(5-CHLORO-2,4-DIMETHOXYPHENYL)-3-(5-CYANOPYRAZIN-2-YL)UREA (2 entities in total)
• Functional Keywords: protein-inhibitor complex, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: O14757
• Total number of polymer chains: 1
• Total formula weight: 31402.47

Authors

Park, C. (deposition date: 2007-04-21, release date: 2007-05-08, Last modification date: 2024-03-13)

• Primary citation: Li, G.,Hasvold, L.A.,Tao, Z.-F.,Wang, G.T.,Gwaltney II, S.L.,Patel, J.,Kovar, P.,Credo, R.B.,Chen, Z.,Zhang, H.,Park, C.,Sham, H.L.,Sowin, T.,Rosenberg, S.H.,Lin, N.-H.; Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors; Bioorg.Med.Chem.Lett., 16:2293-2298, 2006; PubMed: 16446090; DOI: 10.1016/j.bmcl.2006.01.028

Experimental method

X-RAY DIFFRACTION (2.9 Å)