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2FAI

Human Estrogen Receptor Alpha Ligand-Binding Domain In Complex With OBCP-2M and A Glucocorticoid Receptor Interacting Protein 1 NR Box II Peptide

Summary for 2FAI
Entry DOI10.2210/pdb2fai/pdb
Related1ZKY 2B1V
DescriptorEstrogen receptor, Nuclear receptor coactivator 2, 4-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-DIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL, ... (4 entities in total)
Functional Keywordsestrogen receptor, lbd, grip peptide, hormone-growth factor receptor complex, hormone/growth factor receptor
Biological sourceHomo sapiens (human)
More
Cellular locationIsoform 1: Nucleus. Isoform 3: Nucleus: P03372
Nucleus: Q15596
Total number of polymer chains4
Total formula weight62768.25
Authors
Rajan, S.S.,Hsieh, R.W.,Sharma, S.K.,Greene, G.L. (deposition date: 2005-12-07, release date: 2006-05-09, Last modification date: 2023-08-30)
Primary citationHsieh, R.W.,Rajan, S.S.,Sharma, S.K.,Guo, Y.,Desombre, E.R.,Mrksich, M.,Greene, G.L.
Identification of ligands with bicyclic scaffolds provides insights into mechanisms of estrogen receptor subtype selectivity.
J.Biol.Chem., 281:17909-17919, 2006
Cited by
PubMed: 16648639
DOI: 10.1074/jbc.M513684200
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

217705

数据于2024-03-27公开中

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