Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

2F4J

Structure of the Kinase Domain of an Imatinib-Resistant Abl Mutant in Complex with the Aurora Kinase Inhibitor VX-680

Summary for 2F4J
Entry DOI10.2210/pdb2f4j/pdb
DescriptorProto-oncogene tyrosine-protein kinase ABL1, CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE (3 entities in total)
Functional Keywordskinase, kinase inhibitor, abl, transferase
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight33636.52
Authors
Young, M.A.,Shah, N.P.,Chao, L.H.,Zarrinkar, P.,Sawyers, P.,Kuriyan, J. (deposition date: 2005-11-23, release date: 2006-01-24, Last modification date: 2023-08-23)
Primary citationYoung, M.A.,Shah, N.P.,Chao, L.H.,Seeliger, M.,Milanov, Z.V.,Biggs, W.H.,Treiber, D.K.,Patel, H.K.,Zarrinkar, P.P.,Lockhart, D.J.,Sawyers, C.L.,Kuriyan, J.
Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680.
Cancer Res., 66:1007-1014, 2006
Cited by
PubMed: 16424036
DOI: 10.1158/0008-5472.CAN-05-2788
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.91 Å)
Structure validation

217705

건을2024-03-27부터공개중

PDB statisticsPDBj update infoContact PDBjnumon