2EXM

Human CDK2 in complex with isopentenyladenine

2EXM の概要

• エントリーDOI: 10.2210/pdb2exm/pdb
• 分子名称: Cell division protein kinase 2, N-(3-METHYLBUT-2-EN-1-YL)-9H-PURIN-6-AMINE (3 entities in total)
• 機能のキーワード: typical protein kinase fold, ligand binding pocket between n-terminal and c-terminal domain, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34179.73

構造登録者

Schulze-Gahmen, U. (登録日: 2005-11-08, 公開日: 2005-12-27, 最終更新日: 2024-02-14)

• 主引用文献: Schulze-Gahmen, U.,Brandsen, J.,Jones, H.D.,Morgan, D.O.,Meijer, L.,Vesely, J.,Kim, S.H.; Multiple modes of ligand recognition: crystal structures of cyclin-dependent protein kinase 2 in complex with ATP and two inhibitors, olomoucine and isopentenyladenine.; Proteins, 22:378-391, 1995; PubMed: 7479711; DOI: 10.1002/prot.340220408

実験手法

X-RAY DIFFRACTION (1.8 Å)