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2CNL

Crystal structures of caspase-3 in complex with aza-peptide epoxide inhibitors.

Summary for 2CNL
Entry DOI10.2210/pdb2cnl/pdb
Related1CP3 1GFW 1I3O 1NME 1NMQ 1NMS 1PAU 1QX3 1RE1 1RHJ 1RHK 1RHM 1RHQ 1RHR 1RHU 2C1E 2C2K 2C2M 2C2O 2CDR 2CJX 2CJY 2CNK 2CNN 2CNO
Related PRD IDPRD_000672
DescriptorCASPASE-3 SUBUNIT P17, CASPASE-3 SUBUNIT P12, AZA-PEPTIDE EPOXIDE, ... (4 entities in total)
Functional Keywordsthiol protease, phosphorylation, cysteine-protease, protease-inhibitor complex, ice, yama, cpp32, clan cd, protease, epoxides, tetramer, apoptosis, aza-peptide, epoxysuccinyl, aza-asp, zymogen, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHOMO SAPIENS (HUMAN)
More
Cellular locationCytoplasm: P42574 P42574
Total number of polymer chains3
Total formula weight29412.78
Authors
Ganesan, R.,Jelakovic, S.,Campbell, A.J.,Li, Z.Z.,Asgian, J.L.,Grutter, M.G.,Powers, J.C. (deposition date: 2006-05-22, release date: 2007-05-22, Last modification date: 2023-11-15)
Primary citationGanesan, R.,Jelakovic, S.,Campbell, A.J.,Li, Z.Z.,Asgian, J.L.,Powers, J.C.,Grutter, M.G.
Exploring the S4 and S1 Prime Subsite Specificities in Caspase-3 with Aza-Peptide Epoxide Inhibitors
Biochemistry, 45:9059-, 2006
Cited by
PubMed: 16866351
DOI: 10.1021/BI060364P
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.67 Å)
Structure validation

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