2CCT

HUMAN HSP90 WITH 5-(5-CHLORO-2,4-DIHYDROXY-PHENYL)-4-PIPERAZIN-1-YL- 2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYLAMIDE

2CCT の概要

• エントリーDOI: 10.2210/pdb2cct/pdb
• 関連するPDBエントリー: 1BYQ 1OSF 1UY6 1UY7 1UY8 1UY9 1UYC 1UYD 1UYE 1UYF 1UYG 1UYH 1UYI 1UYK 1UYL 1YC1 1YC3 1YC4 1YER 1YES 1YET 2BSM 2BT0 2BYH 2BYI 2BZ5 2C2L 2CCS 2CCU
• 分子名称: HEAT SHOCK PROTEIN HSP-90 ALPHA, 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-PIPERAZIN-1-YL-1H-PYRAZOLE-3-CARBOXAMIDE (3 entities in total)
• 機能のキーワード: heat-shock protein complex, hsp90, atpase, pyrazole, chaperone, atp-binding, heat shock, nucleotide-binding, phosphorylation
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Nucleus : P07900
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26981.62

構造登録者

Barril, X.,Beswick, M.C.,Collier, A.,Drysdale, M.J.,Dymock, B.W.,Fink, A.,Grant, K.,Howes, R.,Jordan, A.M.,Massey, A.,Surgenor, A.,Wayne, J.,Workman, P.,Wright, L. (登録日: 2006-01-18, 公開日: 2006-02-22, 最終更新日: 2018-03-28)

• 主引用文献: Barril, X.,Beswick, M.C.,Collier, A.,Drysdale, M.J.,Dymock, B.W.,Fink, A.,Grant, K.,Howes, R.,Jordan, A.M.,Massey, A.,Surgenor, A.,Wayne, J.,Workman, P.,Wright, L.; 4-Amino derivatives of the Hsp90 inhibitor CCT018159.; Bioorg. Med. Chem. Lett., 16:2543-2548, 2006; PubMed: 16480864; DOI: 10.1016/j.bmcl.2006.01.099

実験手法

X-RAY DIFFRACTION (2.3 Å)