2C2Z

Crystal structure of caspase-8 in complex with aza-peptide Michael acceptor inhibitor

Summary for 2C2Z

• Entry DOI: 10.2210/pdb2c2z/pdb
• Related: 1F9E 1I4E 1QDU 1QTN 2FUN
• Related PRD ID: PRD_000336
• Descriptor: CASPASE-8 P18 SUBUNIT, CASPASE-8 P10 SUBUNIT, AZA-PEPTIDE INHIBITOR (5S, 8R, 11S)-8-(2-CARBOXYETHYL) -14-[4-(3,4-DIHYDROQUINOLIN-1(2H)-YL)-4-OXOBUTANOYL] -11-[(1R)-1-HYDROXYETHYL]-5-(2-METHYLPROPYL)-3,6,9,12-TETRAOXO -1-PHENYL-2-OXA-4,7,10,13,14-PENTAAZAHEXADECAN-16-OIC ACID, ... (5 entities in total)
• Functional Keywords: hydrolase-hydrolase inhibitor complex, apoptosis, cysteine-protease, ice, thiol protease, zymogen, cpp32, yama, aza-peptide, michael acceptor, aza-asp, clan cd, hydrolase/hydrolase inhibitor
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Cytoplasm: Q14790 2C2Z
• Total number of polymer chains: 3
• Total formula weight: 31219.93

Authors

Ganesan, R.,Jelakovic, S.,Ekici, O.D.,Li, Z.Z.,James, K.E.,Asgian, J.L.,Campbell, A.J.,Mikolajczyk, J.,Salvesen, G.S.,Powers, J.C.,Gruetter, M.G. (deposition date: 2005-10-02, release date: 2006-09-20, Last modification date: 2017-02-08)

• Primary citation: Ekici, O.D.,Li, Z.Z.,Campbell, A.J.,James, K.E.,Asgian, J.L.,Mikolajczyk, J.,Salvesen, G.S.,Ganesan, R.,Jelakovic, S.,Grutter, M.G.,Powers, J.C.; Design, Synthesis, and Evaluation of Aza-Peptide Michael Acceptors as Selective and Potent Inhibitors of Caspases-2, -3, -6, -7, -8, -9, and - 10.; J.Med.Chem., 49:5728-, 2006; PubMed: 16970398; DOI: 10.1021/JM0601405

Experimental method

X-RAY DIFFRACTION (1.95 Å)