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2BR1

Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity

Summary for 2BR1
Entry DOI10.2210/pdb2br1/pdb
Related1IA8 1NVQ 1NVR 1NVS 2BRB 2BRG 2BRH 2BRM 2BRN 2BRO
DescriptorSERINE/THREONINE-PROTEIN KINASE CHK1, 2-[5,6-BIS-(4-METHOXY-PHENYL)-FURO[2,3-D]PYRIMIDIN-4-YLAMINO]-ETHANOL, SULFATE ION, ... (4 entities in total)
Functional Keywordstransferase, drug design, furanopyrimidine, molecular recognition, oncology, pyrrolopyrimidine, kinase
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains1
Total formula weight34731.69
Authors
Foloppe, N.,Fisher, L.M.,Howes, R.,Kierstan, P.,Potter, A.,Robertson, A.G.S.,Surgenor, A.E. (deposition date: 2005-04-29, release date: 2005-05-12, Last modification date: 2023-12-13)
Primary citationFoloppe, N.,Fisher, L.M.,Howes, R.,Kierstan, P.,Potter, A.,Robertson, A.G.S.,Surgenor, A.E.
Structure-Based Design of Novel Chk1 Inhibitors: Insights Into Hydrogen Bonding and Protein-Ligand Affinity.
J.Med.Chem., 48:4332-, 2005
Cited by
PubMed: 15974586
DOI: 10.1021/JM049022C
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

217705

건을2024-03-27부터공개중

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