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2B54

Human cyclin dependent kinase 2 (CKD2)complexed with DIN-232305

Summary for 2B54
Entry DOI10.2210/pdb2b54/pdb
Related2B52 2B53 2B55
DescriptorCell division protein kinase 2, 6-(3,4-DIHYDROXYBENZYL)-3-ETHYL-1-(2,4,6-TRICHLOROPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4(5H)-ONE (3 entities in total)
Functional Keywordsprotein kinase, cell cycle, phosphorylation, cell division, mitosis, inhibition, transferase
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight34442.20
Authors
Chang, C.-C. (deposition date: 2005-09-27, release date: 2005-10-11, Last modification date: 2024-02-14)
Primary citationMarkwalder, J.A.,Arnone, M.R.,Benfield, P.A.,Boisclair, M.,Burton, C.R.,Chang, C.-C.,Cox, S.S.,Czerniak, P.M.,Dean, C.L.,Dolenaik, D.,Grafstrom, R.,Harrison, B.A.,Kaltenbach III, R.F.,Nugiel, D.A.,Rossi, K.A.,Sherk, S.R.,Sisk, L.M.,Stouten, P.,Trainor, G.L.,Worland, P.,Seitz, S.P.
Synthesis and biological evaluation of 1-aryl-4,5-dihydro-1h-pyraxolo[3,4-d]pyrimidin-4-one inhibitors of cyclin dependent kinases
J.Med.Chem., 47:5894-5911, 2004
Cited by
PubMed: 15537345
DOI: 10.1021/jm020455u
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.85 Å)
Structure validation

217705

건을2024-03-27부터공개중

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