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2AOB

Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain

Summary for 2AOB
Entry DOI10.2210/pdb2aob/pdb
DescriptorGrowth factor receptor-bound protein 2, 2-(4-((9S,10S,14S,Z)-18-(2-AMINO-2-OXOETHYL)-9-(CARBOXYMETHYL)-14-(NAPHTHALEN-1-YLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL)PHENYL)MALONIC ACID (3 entities in total)
Functional Keywordsgrb2 sh2, peptide mimetic, domain swapping, kinase signalling, transferase
Biological sourceHomo sapiens (human)
Cellular locationNucleus : P62993
Total number of polymer chains4
Total formula weight55358.52
Authors
Phan, J.,Shi, Z.D.,Burke, T.R.,Waugh, D.S. (deposition date: 2005-08-12, release date: 2005-10-04, Last modification date: 2024-02-14)
Primary citationPhan, J.,Shi, Z.D.,Burke, T.R.,Waugh, D.S.
Crystal Structures of a High-affinity Macrocyclic Peptide Mimetic in Complex with the Grb2 SH2 Domain.
J.Mol.Biol., 353:104-115, 2005
Cited by
PubMed: 16165154
DOI: 10.1016/j.jmb.2005.08.037
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

217705

數據於2024-03-27公開中

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